Markus Fendt Selected Research

almorexant

10/2013	Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
1/2013	Distinct effects of IPSU and suvorexant on mouse sleep architecture.
12/2012	The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.

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Markus Fendt Research Topics

Disease

8	Anxiety Disorders (Anxiety Disorder) 05/2021 - 01/2020
6	Narcolepsy 01/2017 - 09/2011
4	Cataplexy 01/2017 - 09/2011
4	Sleep Initiation and Maintenance Disorders (Insomnia) 10/2015 - 01/2013
3	Mental Disorders (Mental Disorder) 05/2021 - 01/2020
2	Schizophrenia (Dementia Praecox) 01/2022 - 01/2021
2	Sleep Wake Disorders 10/2013 - 01/2013
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2022
1	Wounds and Injuries (Trauma) 01/2021
1	Central Nervous System Infections (Central Nervous System Infection) 09/2020
1	Gliosis 01/2017
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2017
1	Memory Disorders (Memory Loss) 01/2017
1	Neuroinflammatory Diseases 01/2017
1	Phobic Disorders (Phobia) 01/2016
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2016
1	Epilepsy (Aura) 10/2015
1	Psychotic Disorders (Schizoaffective Disorder) 10/2015
1	Inflammation (Inflammations) 10/2015
1	Pain (Aches) 10/2015
1	Parkinson Disease (Parkinson's Disease) 11/2011
1	Shock 02/2004

Drug/Important Bio-Agent (IBA)

6	OrexinsIBA 01/2022 - 09/2011
3	almorexantIBA 10/2013 - 12/2012
2	NeuropeptidesIBA 01/2020 - 01/2020
2	Orexin Receptor AntagonistsIBA 10/2013 - 01/2013
2	suvorexantIBA 10/2013 - 01/2013
2	Orexin ReceptorsIBA 10/2013 - 01/2013
1	Oxytocin (Pitocin)FDA LinkGeneric 05/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	Viral RNAIBA 09/2020
1	human neuropeptide SIBA 01/2020
1	Hormones (Hormone)IBA 01/2020
1	methysticinIBA 01/2017
1	CytokinesIBA 01/2017
1	Interleukin-17 (Interleukin 17)IBA 01/2017
1	Antidepressive Agents (Antidepressants)IBA 01/2016
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2016
1	Complement System Proteins (Complement)IBA 01/2016
1	Serotonin (5 Hydroxytryptamine)IBA 01/2016
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2015
1	Modafinil (Provigil)FDA Link 01/2015
1	Pharmaceutical PreparationsIBA 08/2014
1	ErgolinesIBA 08/2014
1	Histamine H3 Receptors (Histamine H3 Receptor)IBA 08/2014
1	MK-6096IBA 01/2013
1	N- ((1- ((5- (4- fluorophenyl)- 2- methyl- 4- thiazolyl)carbonyl)- 2- piperidinyl)methyl)- 4- benzofurancarboxamideIBA 01/2013
1	SynucleinsIBA 11/2011
1	Dopamine (Intropin)FDA LinkGeneric 11/2011
1	MuscimolIBA 02/2004

Therapy/Procedure

4	Therapeutics 05/2021 - 01/2020
1	Oral Administration 01/2017
1	Traditional Medicine (Folk Remedies) 10/2015
1	Injections 02/2004